Abstract
The synthesis of purines in Aerobacter aerogenes was studied by culturing the organism in a dextrose-ammonium sulfate medium with added isotopically labeled compounds. Glycine is incorporated into the 4, 5, and 7 positions of adenine and guanine of bacterial nucleic acids. Carbon dioxide is incorporated into position 6 of these purine bases, and into positions 2 plus 8 through reduction to formate. Acetate does not play a role in bacterial purine synthesis. Nitrogen atoms in positions 1,3, and 9 arise from the nitrogen of ammonium sulfate either directly or through some donor system. The synthesis of adenine and guanine by the same mechanisms present in animal tissue is indicated.
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