Abstract
Analyses of the carbohydrate content of eleven IgA1 and six IgA2 myeloma proteins revealed that, besides the known restriction of galactosamine to IgA1 subclass (1,2), statistically significant quantitative differences exist between the carbohydrate composition of the two subclasses. The greater amounts of fucose, mannose, and galactosamine in IgA2 immunoglobulins explain the higher total carbohydrate content of these proteins (Table 1). No statistical differences were found in the galactose and sialic acid content of the subclasses. The relatively high content of fucose in IgA2 immunoglobulins suggests that these proteins contain more highly branched oligosaccharides than proteins of the IgA1 subclass.KeywordsSialic AcidAmmonium BicarbonateCarbohydrate CompositionSialic Acid ContentAmmonium Bicarbonate BufferThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Published Version
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