Abstract
A mathematical model is developed which allows the concentrations of the five individual species in a solution comprising cyclodextrin, drug and competitor (i.e. free drug, free competitor, complexed drug, complexed competitor and uncomplexed cyclodextrin) to be calculated. The cubic equation is solved by Newton-Raphson iteration to provide the concentration of free drug in the system ([A]) and a BASIC program is presented which undertakes the calculations automatically. Application to simpler cases, for example, the absence of competitor or the dissolution of a 1:1 complex, are identified and the effect of variables on the fraction of free drug is illustrated.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
