Abstract
The calcium-ROS-pH triangle and mitochondrial permeability transition: challenges to mimic cardiac ischemia-reperfusion.
Highlights
Specialty section: This article was submitted to Mitochondrial Research, a section of the journal Frontiers in Physiology
Reperfusion of the heart following sustained ischemia is associated with enhanced reactive oxygen species (ROS) production, Ca2+ accumulation, and pHi normalization that are the major inducers of mitochondrial permeability transition
Genetic studies from different groups demonstrated that pore opening can occur in the absence of these proteins indicating that they are not involved in the mPT pore (mPTP) structure
Summary
Specialty section: This article was submitted to Mitochondrial Research, a section of the journal Frontiers in Physiology. Reperfusion of the heart following sustained ischemia is associated with enhanced reactive oxygen species (ROS) production, Ca2+ accumulation, and pHi normalization that are the major inducers of mitochondrial permeability transition (mPT). In addition to the unknown molecular identity of the mPT pore (mPTP), a lack of in vitro models mimicking cardiac ischemia-reperfusion (IR) makes it difficult to elucidate the precise role of mitochondrial ROS, Ca2+, and pHi in response to oxidative stress.
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