Abstract
BackgroundVentricular premature complex (VPC) is one of the most common ventricular arrhythmias. The presence of VPC is associated with an increased risk of heart failure (HF).MethodWe designed a single-center, retrospective, and large population-based cohort to clarify the role of VPC burden in long-term prognosis in Taiwan. We analyzed the database from the National Cheng Kung University Hospital-Electronic Medical Record (NCKUH-EMR) and NCKUH-Holter (NCKUH-Holter). A total of 19,527 patients who underwent 24-h Holter ECG monitoring due to palpitation, syncope, and clinical suspicion of arrhythmias were enrolled in this study.ResultsThe clinical outcome of interests involved 5.65% noncardiovascular death and 1.53% cardiovascular-specific deaths between 2011 and 2018. Multivariate Cox regression analysis, Fine and Gray's competing risk model, and propensity score matching demonstrated that both moderate (1,000–10,000/day) and high (>10,000/day) VPC burdens contributed to cardiovascular death in comparison with a low VPC burden (<1,000/day).ConclusionA higher VPC burden via Holter ECG is an independent risk factor of cardiovascular mortality.
Highlights
Ventricular premature complex (VPC) is one of the most common ventricular arrhythmias and is strongly associated with heart failure (HF), all-cause hospitalization, and cardiovascular hospitalization [1,2,3]
The accumulated data demonstrate that the elimination of VPC by either catheter ablation or antiarrhythmic drugs (AADs) relieves symptoms and improves the left ventricular systolic function in patients with preexisting left ventricular systolic dysfunction or VPC-induced cardiomyopathy [6,7,8,9,10]
The presence of exercise-induced VPC was reported to be associated with cardiovascular death, the effect of VPC burden on cardiovascular death has not been directly reported until a recent subgroup analysis from the CHF-STAT study demonstrated that amiodarone could suppress PVC burden and improve survival [10, 13, 14]
Summary
Ventricular premature complex (VPC) is one of the most common ventricular arrhythmias and is strongly associated with heart failure (HF), all-cause hospitalization, and cardiovascular hospitalization [1,2,3]. Several significant clinical comorbidities could be confounding factors for all-cause death and cardiovascular death These factors include age, coexisting diseases like diabetes mellitus (DM), chronic kidney disease (CKD), and stroke, the presence of ventricular tachycardia, and HF. The presence of exercise-induced VPC was reported to be associated with cardiovascular death, the effect of VPC burden on cardiovascular death has not been directly reported until a recent subgroup analysis from the CHF-STAT study demonstrated that amiodarone could suppress PVC burden and improve survival [10, 13, 14]. The presence of VPC is associated with an increased risk of heart failure (HF)
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call