Abstract
In order to improve the risk identification ability of the technical support system of food safety supervision, an online screening platform for food risk substances (hereafter referred to as “platform”) was established. The platform aims at the qualitative analysis of unknown compounds and consists of three parts: a standard spectrum library, screening model, and online comparison module. The standard library contains the standard spectra of 527 food risk substances by high-performance liquid chromatography/high-resolution mass spectrometry. The screening comparison algorithm, the core of the screening model, is obtained through the improvement of the existing spectral library search algorithm. The inspector uploads the original spectrum file through the online comparison module; the online comparison module calls the corresponding script to convert the original spectrum file into a standard spectrum file and then uses the screening and comparison algorithm to achieve online real-time comparison. The comparison results are used to determine whether the sample to be tested contains the food risk substances contained in the standard library, so as to realize the preliminary screening of potential food risk substances. The platform supports the spectrogram data format of mainstream instrument manufacturers. The standard spectrogram database can be coconstructed and shared by cooperative laboratories to effectively enrich the types of food risk substances. Through laboratory comparison, data calibration, and model optimization, the screening accuracy of the platform can reach more than 97%. The platform adopts the Internet online screening method, which greatly facilitates the risk investigation and control of national food safety inspection and testing institutions. At the same time, the construction of the screening platform for food risk substances based on high-performance liquid chromatography/high-resolution mass spectrometry, the Internet, big data, and other technologies will provide a new technical means for food safety risk management and control. Hence, it can build a bridge between the screening of risk substances and illegally added substances, as well as risk assessment, risk management, and control.
Highlights
With the development of the market economy and the improvement of the country’s overall strength, China, the largest food producer and consumer since 2010 has a gradually increasing food quality
Because of the large amount of food consumption and the long food industrial chain, China has witnessed numerous food safety incidents, which have aroused widespread concern in society. e Chinese government has increased the monitoring of food risks through a series of policies and measures and has established a food safety risk management and control mechanism based on source control, process control, and end-product monitoring
In view of the high selectivity and high sensitivity of mass spectrometry (MS) in the qualitative and Journal of Food Quality quantitative analysis of trace substances, many countries rely on gas chromatography (GC)–MS and Liquid chromatography (LC)–MS [2,3,4] and other analytical techniques in the detection and screening of food risk substances
Summary
The Bridge between Screening and Assessment: Establishment and Application of Online Screening Platform for Food Risk Substances. E standard library contains the standard spectra of 527 food risk substances by high-performance liquid chromatography/high-resolution mass spectrometry. The construction of the screening platform for food risk substances based on high-performance liquid chromatography/high-resolution mass spectrometry, the Internet, big data, and other technologies will provide a new technical means for food safety risk management and control. It can build a bridge between the screening of risk substances and illegally added substances, as well as risk assessment, risk management, and control
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