Abstract
The role of O-alkyl lipids as precursors for plasmalogens has been investigated in vivo. We have demonstrated that rac- O-[ i- 14C]hexadecyl[2- 3H]glycerol (chimyl alcohol) is incorporated into O-alkyl lipids by intact Ehrlich ascites cells and is subsequently converted to plasmalogens having essentially the same 3H/ 14C ratio as the chimyi alcohol administered. A labeled O-alkylglycerol intermediate with a polar group in the O-alkyl moiety was found in these studies and it had the same 3H/ 14C ratio as the O-alkyl and O- alk- i- enyl lipids. The unidentified O-alkyl lipid has a number of Chromatographie properties that are similar to those of synthetic i- O-( β-hydroxy) hexadecyl glycerol. Our data indicate that O-alkyl lipids are converted to O- alk- i-enyl lipids via a substitution reaction on the O-alkyl moiety.
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