Abstract
Lung cancer is characterized by high morbidity and mortality rates, and it has become an important public health issue worldwide. The occurrence and development of tumors is a multi-gene and multi-stage complex process. As an oncogene, ribosomal oxygenase 2 (RIOX2) has been associated with a variety of cancers. In this article, we analyzed the correlation between RIOX2 expression and methylation in lung cancer based on the databases including the cancer genome atlas (TCGA) (https://portal.gdc.cancer.gov/) and the gene expression omnibus (GEO) (https://www.ncbi.nlm.nih.gov/geo/). It was found that RIOX2 is highly expressed in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) tissues, whose expression is negatively correlated with its methylation level. In this regard, methylation at cg09716038, cg14773523, cg14941179, and cg22299097 had a significant negative correlation with RIOX2 expression in LUAD, whereas in LUSC, methylation at cg09716038, cg14773523, cg14941179, cg22299097, cg05451573, cg10779801, and cg23629183 is negatively correlated with RIOX2 expression. According to the analysis based on the databases, RIOX2 gene could not be considered as the independent prognostic biomarker in lung adenocarcinoma or squamous cell lung cancer. However, the molecular mechanism of RIOX2 gene in the development of lung cancer may be helpful in improving lung cancer therapy.
Highlights
Cancer is a major public health problem worldwide and an important cause of death in many countries
Results showed that ribosomal oxygenase 2 (RIOX2) expression had an overall increasing trend in both groups (p = 1.064e-15) but it was higher in carcinoma tissues (Fig 1)
lung adenocarcinoma (LUAD) and para-carcinoma tissue datasets were selected from the gene expression omnibus (GEO) database(https://www.ncbi.nlm.nih.gov/geo/)
Summary
Cancer is a major public health problem worldwide and an important cause of death in many countries. Lung cancer is the important cause of death in patients with malignant tumors [1]. It is generally accepted that smoking is a major risk factor for lung cancer, but in recent years, the rising incidence of non-smoking patients suggests that other factors in the development of lung cancer have played an important role, such as living environment and occupational exposure [2,3,4]. Lung cancer can be divided into two histological types: non-small cell lung cancer and small cell lung cancer.
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