The beta sector of the rabbit's dorsal lateral geniculate nucleus.

Abstract

The beta sector of the rabbit's dorsal lateral geniculate nucleus is a small region of nerve cells scattered among the fibres of the geniculocortical pathway. In its topographical relations it resembles the perigeniculate nucleus of carnivores, which contains neurons driven by geniculate and visual cortical neurons and which sends inhibitory fibres back into the geniculate relay. We have traced retinogeniculate, geniculocortical and corticogeniculate pathways in rabbits by using horseradish peroxidase or radioactively labelled proline and have found that the beta sector resembles the perigeniculate nucleus in receiving no direct retinal afferents, sending no efferents to the visual cortex (V-I), and receiving afferents from the visual cortex. The corticogeniculate afferents are organized so that the visual field map in the beta sector and the main part of the lateral geniculate relays are aligned, as are the maps in the cat's perigeniculate nucleus and the main part of the geniculate relay of carnivores. Electron microscopical studies show similar types of axon terminals in the rabbit and the cat for the main part of the geniculate relay on the one hand and for the beta sector and the perigeniculate nucleus on the other. Earlier observations that the proportion of putative inhibitory terminals (F-type terminals) is lower in the rabbit's than the cat's geniculate region are confirmed. A major difference between the beta sector and the perigeniculate nucleus has been revealed by immunohistochemical staining for GABA. Whereas almost all of the cat's perigeniculate cells appear to be GABAergic, the proportion in the beta sector is much lower, and not significantly different from that found in the main part of the rabbit's geniculate relay. It is concluded that the beta sector shares many of the organizational features of the perigeniculate nucleus. A common developmental origin seems probable, but the functional differences remain to be explored.