Abstract
Over the past two decades, obesity has been one of the major public health concerns in most countries. In the search for new molecules that could be used for the treatment of obesity, good perspectives have been opened up for polyphenols, a class of natural bioactive phytochemicals. Experimental and limited clinical trial evidence supports that some polyphenols such as quercetin, curcumin, and resveratrol have potential benefit functions on obesity treatment. This brief review focuses on the main functions of the above-named polyphenols on adipose tissue. These polyphenols may play beneficial effects on adipose tissue under obese condition by alleviating intracellular oxidative stress, reducing chronic low-grade inflammation, inhibiting adipogenesis and lipogenesis, and suppressing the differentiation of preadipocytes to mature adipocytes.
Highlights
Over the past decades, obesity has been one of the major public health threats in most developed countries and in an increasing number of developing countries [1]
It is well known that obesity is a strong risk factor for type 2 diabetes mellitus (T2DM) and cancer, and T2DM is linked to the development of cardiovascular diseases, such as hypertension and atherosclerosis [3, 4]
Under normal physiological lean state, when the body takes excessive energy, adipose tissue can be rapidly enlarged by increasing the adipocyte size and numbers, which were accompanied by an increase of blood vessels to supply more oxygen (O2) and nutrients to the whole tissue [7]
Summary
Obesity has been one of the major public health threats in most developed countries and in an increasing number of developing countries [1]. Under pathological obese state, adipose tissue will undergo a process named “adipose tissue remodeling,” which was characterized by reduced angiogenesis, Oxidative Medicine and Cellular Longevity increased hypoxia levels and extra cellular matrix (ECM) levels, and induced higher levels of immune cell infiltration and subsequently induced a low-grade chronic inflammation. All of these pathological events will lead to adipocyte dysfunction, cell death, and systemic insulin resistance [7]. We will focus on the roles of and the mechanisms of polyphenols including quercetin, curcumin, and resveratrol and on obesity and adipose tissue function
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