Abstract
Extensive soft-tissue uptake after strenuous physical exercise and/or trauma has been observed with bone scanning agents. Reports since 1984 suggest that muscle damage secondary to strenuous exertion is more common than realized, an observation that has assumed an important role in the last decade because of the evolution of sports medicine practices. Furthermore, although localization of the phosphate bone scanning agents following exercise has been recognized since 1978, there is no one explanation for the exact mechanism by which these bone-seeking agents are concentrated in injured skeletal tissues and muscles.
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