Abstract
Objective To investigate the effects of ziprasidone on the behavior and the expression of pERK1/2 in posttraumatic stress disorder(PTSD) model rats. Methods 24 adult male SD rats weighing (200±20)g were randomly divided into four groups (n=6): control group, single prolonged stress and foot shock(SPS&S) group, ziprasidone group and ziprasidone+ U0126 group. The fear response to environment, high alertness, and anxiety & depression behavior of rats were tested by the open field, elevated plus-maze, and the expression of pERK1/2 was measured by Western blot. Results In open field test(OFT), the SPS&S group((76.23±54.76)cm for horizontal motion distance, (4.60±1.14)for the number of entering central region) showed significant difference compared with control group((343.77±74.22)cm, (12.40±3.36)) or ziprasidone group((274.98±83.56)cm, (12.00±2.92))(P 0.05). The results of elevated plus maze (EPM) were in accordance with the results of OFT. The expression of pERK1/2 in SPS&S group and ziprasidone+ U0126 group showed significant decrease when compared with control group or ziprasidone group(P<0.01). Conclusion Ziprasidone can obviously improve fear response to environment, high alterness and anxiety & depression behavior of rats, and these effects of ziprasidone may be carried out by up-regulation the expression of pERK1/2. Key words: Ziprasidone; Posttraumatic stress disorder; Phosphorylated extracellular signal-regulatedprotein kinase; Rat
Published Version
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