The balance between Treg and TH17 cells: CD11b and interleukin-6.

Abstract

One of the gold standards for animal models of rheumatoid arthritis is the murine collagen-induced arthritis model. Native type II collagen together with CFA is injected into susceptible mouse strains. Unfortunately, only mice with H-2q or H-2r MHC haplotypes are susceptible, making the widely used C57BL/6 mouse strain, which carries the H-2b haplotype, resistant against the disease. In this issue of the European Journal of Immunology, Stevanin etal. [Eur. J. Immunol. 2017. 47: 637-645] now convincingly show that although WT C57BL/6 mice are resistant to collagen-induced arthritis, mice with a homozygous deletion of CD11b on the same genetic background are fully susceptible in this important animal model of rheumatoid arthritis. They clearly demonstrate that the injection of type II collagen together with CFA leads to early onset of the disease with high incidence and with sustained severity. The authors further characterize this disease with an increase of leukocyte infiltration and enhanced TH17 differentiation.