Abstract
Part 1 Cellular mechanisms in rheumatoid arthritis: histopathology of rheumatoid joint, T. Freemont pannus, D. Hamerman synovial cells, B. Henderson and J. Edwards chrondrocytes, R. Poole bone cells and bone remodelling in rheumatoid arthritis, M. Gowen t lymphocyte/macrophage interactions, L. Klareskog leukocyte adhesion and leukocyte traffic in rheumatoid arthritis, D. Haskard. Part 2 Humoral mechanisms in rheumatoid arthritis: inflammatory cytokines including the IL-8 supergene family, S. Kunkel cytokine inhibitors, B. Thompson growth factors, R. Wilder lipid mediators, G. Higgs oxidants/free radicals, B. Halliwell neuropeptides, J. Levine proteases and connective tissue breakdown, J. Reynolds. Part 3 Animal models of rheumatoid arthritis: role of animal models in the study of rheumatoid arthritis - a general review, D. Willoughby immunogenetics of animal models of rheumatoid arthritis, P. Woolley adjuvant arthritis - the first model?, M. Billingham arthritis induced by bacteria and viruses, B. Cole streptococcal cell wall arthritis, J. Schwab collagen-induced arthritis, D. Trentham antigen-induced arthritis in rodents, W. Van den Berg antigen-induced arthritis in the rabbit, R. Pettipher and B. Henderson. Part 4 Animal models of rheumatoid arthritis: spontaneous arthritis models, S. Gay cytokine-induced arthritis, I. Otterness animal models and anti-rheumatic drug development, R. Griffiths.
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