Abstract
Progress in science is a history of the synergistic relationship between technology and theory: growth in theoretical understanding requires and initiates technological change; technological advance opens up new areas of knowledge. The history of molecular genetics is but a single illustration of this process. Four major achievements in understanding DNA have occurred in recent years: they are the use of X-ray diffraction to posit a model for DNA, the discovery of DNA cutting enzymes, the sequencing of DNA, and the chemical synthesis of DNA. This last achievement, the chemical synthesis of DNA, and, more particularly, its automation, will be the focus of this article.
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