Abstract
Background and objective: The hepatitis C virus (HCV) is able to cause a life-threatening disease relating to lethal hepatocellular carcinoma. Previous, Toll-like receptor polymorphisms were proposed as promising biomarker for HCV-related hepatocellular carcinoma and disease progression. This study aimed to summarize the association of TLR4 polymorphisms and HCV infection through meta-analysis.Methods: We applied a systematic review and meta-analysis performed by using PubMed, EMBASE and Web of Science searches. The Modified Newcastle-Ottawa scale was used for quality assessment. The odd-ratio (OR) and 95% confidence interval (CI) were calculated to assess the association. In silico analysis was applied for proposing the function as microRNA (miRNA) of non-coding polymorphism. Finally, the miRNA target was predicted and annotated to suggest the possible relationship between polymorphism and HCV infection.Results: Our meta-analysis incorporated seven studies involving rs4986791, rs4986790 and rs2149356. No association exists between rs4986791 and HCV infection. However, the heterozygous model (AG vs GG) of rs4986790 significantly associates with HCV infection (OR = 0.33, 95% CI = 0.21–0.49, P<0.0001). Moreover, the rs2149356 TG genotype also associates with HCV infection in the over-dominant model (TG vs TT+TG: OR = 0.54, 95% CI = 0.40–0.75). In silico analysis of rs2149356G allele showed that this mutation is siRNA, which targets the set of genes, especially in the autophagy pathway.Conclusion: We demonstrated that rs4986790 and rs2149356 are associated with HCV infection.
Highlights
Received: 27 December 2018Revised: February 2019Accepted: February 2019Accepted Manuscript Online: 14 February 2019Version of Record published: 26 February 2019Hepatitis C virus (HCV), which is composed of 6 genotypes and 90 subtypes, causes a disease that is life-threatening to mankind since it is associated with highly lethal hepatocellular carcinoma [1,2]
No association exists between rs4986791 and hepatitis C virus (HCV) infection
We demonstrated that rs4986790 and rs2149356 are associated with HCV
Summary
Received: 27 December 2018Revised: February 2019Accepted: February 2019Accepted Manuscript Online: 14 February 2019Version of Record published: 26 February 2019Hepatitis C virus (HCV), which is composed of 6 genotypes and 90 subtypes, causes a disease that is life-threatening to mankind since it is associated with highly lethal hepatocellular carcinoma [1,2]. Version of Record published: 26 February 2019. Hepatitis C virus (HCV), which is composed of 6 genotypes and 90 subtypes, causes a disease that is life-threatening to mankind since it is associated with highly lethal hepatocellular carcinoma [1,2]. HCV infection is a silent pandemic [4]. The vast majority of patients infected with HCV are inapparent cases that cause viral circulation in the population. Acute infection is capable of progressing into a chronic disease, cirrhosis and HCC, resulting in an estimated 700,000 deaths per year [5,6]. The hepatitis C virus (HCV) is able to cause a life-threatening disease relating to lethal hepatocellular carcinoma. Toll-like receptor polymorphisms were proposed as promising biomarker for HCV-related hepatocellular carcinoma and disease progression. This study aimed to summarize the association of TLR4 polymorphisms and HCV infection through meta-analysis
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