Abstract
Objective To explore the association of hypertension and higher levels of blood lipids and sugar (three high factors) with the onset of coronary artery disease.Methods From June 2005 to January 2009,276 hospitalized patients with suspected coronary heart disease underwent coronary angiography by sixteen-slice spiral CT. The patients were divided into two groups with or without coronary artery disease according to the findings of cardiac CTA. Chi square test,binary logistic regression,mean comparison and receiver operating characteristic (ROC) curves were used to analyze the association of three high factors with the onset of coronary artery disease. Results Chi square test showed that the onset of coronary heart disease was affected by age (χ2=13.560,P=0.001),total cholesterol (TC) (χ2=8.260,P=0.004),triglyceride (TG) (χ2=5.718,P=0.017),and low density lipoprotein (LDL) (χ2=6.375,P=0.012).Logistic regression exhibited that the onset of coronary heart disease closely correlated to TC (OR=1.967,P=0.000) and age (OR=1.046,P=0.004). Serum levels of TC (t=3.387,P=0.001) and LDL (t=3.662,P=0.000) increased significantly in patients with coronary heart disease compared with those without coronary heart disease. The areas under the ROC cures of TC,TG,HDL and LDL to predict the onset of coronary heart disease was 0.655,0.473,0.569,and 0.640,respectively. Conclusions Among the three high factors,serum TC level shows the closest association with the onset of coronary artery disease,followed by LDL level; blood presure and sugar don't show any association. However,serum levels of TC and LDL could hardly predict the onset of coronary heart disease. Key words: Coronary artery disease; Hypertension; Blood lipids; Blood sugar
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call