Abstract
BackgroundThe role of circadian rhythm abnormalities in patients with inflammatory bowel disease (IBD) remains relatively unknown. The aim of this study was to identify the inflammatory cytokine profile in the IBD patients and its relationship with the quality of sleep.MethodsProspective, single-center observational cohort study was performed. In all enrolled adult IBD patients, the disease activity was assessed using Crohn’s Disease Activity Index (CDAI) for Crohn’s disease (CD) and Partial Mayo Score for ulcerative colitis (UC), respectively. To assess the quality of sleep, all patients were asked to respond to a questionnaire to define Pittsburgh Quality Sleep Index (PSQI). From all enrolled patients, 15 ml venous blood was taken to determine serum inflammatory cytokine levels and perform standard laboratory tests.ResultsFifty-two IBD patients were enrolled in the study: 32 with CD and 20 with UC. The poor sleep was noted in 69.4% of patients with clinically active and in 6.3% of patients with inactive disease. In the group of IBD patients with poor sleep, the significantly higher level of serum IL-6, IL-17, and IL-23 were observed. In IBD patients with exacerbation, the significantly higher level of serum IL-6, IL-17, and IL-23 were recorded.ConclusionsThe relationship between quality of sleep and proinflammatory cytokine profile may show us a predisposition for the development of inflammatory intestinal lesions in IBD patients with sleep disturbances. This knowledge may allow the pharmacological and behavioral therapies of circadian rhythm abnormalities to become new significant targets in IBD patients.
Highlights
MethodsInflammatory bowel disease (IBD), including two main representatives Crohn’s disease (CD) and ulcerative colitis (UC), are chronic health problems of difficult management and treatment
The poor sleep was noted in 50.0% (26/52) of inflammatory bowel disease (IBD) patients enrolled to our study: in 69.4% (25/36) patients with clinically active and in 6.3% (1/16) patients with inactive disease (p = 0.001; OR 34.1, 95% confidence interval, 3.9–291.2)
There was no relationship between Pittsburgh Quality Sleep Index (PSQI) score and subtype of IBD
Summary
MethodsInflammatory bowel disease (IBD), including two main representatives Crohn’s disease (CD) and ulcerative colitis (UC), are chronic health problems of difficult management and treatment. In our previous observational study, a strong relationship between clinically active IBD and sleep disturbances was observed [7, 8] This finding may indicate circadian rhythm disorders as a risk factor of exacerbation of IBD. Conclusions The relationship between quality of sleep and proinflammatory cytokine profile may show us a predisposition for the development of inflammatory intestinal lesions in IBD patients with sleep disturbances. This knowledge may allow the pharmacological and behavioral therapies of circadian rhythm abnormalities to become new significant targets in IBD patients
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