The association of leptin with dyslipidemia, arterial hypertension and obesity in Kyrgyz (Central Asian nation) population.

Erkin М Мirrakhimov,Erkin М Мirrakhimov,Erkin М Мirrakhimov,Asiyat A Bayramukova,Alina S Kerimkulova,Malik P Nabiev,Nurdin Satarov,Aibek E Mirrakhimov,Оlga S Lunegova,Nazira T Alibaeva,Kseniya V Neronova

doi:10.1186/1756-0500-7-411

Abstract

BackgroundLeptin, an adipocytokine produced by adipose tissue, along with the traditional cardiometabolic risk factors, contributes to the development of cardiovascular complications. At the same time, ethnic features of adipocytokines have been insufficiently investigated, especially among Asians, who have an increased risk of cardiovascular complications compared with Europeans. Aim of study was to investigate the relationship between leptin levels and age, gender, anthropometric parameters, lipid parameters, arterial hypertension (AH), and obesity in the adult population of ethnic Kyrgyz people living in Central Asia.ResultsIn total, 322 ethnic Kyrgyz (145 men, 177 women) aged ≥ 30 years were studied. Waist and hip circumference, body mass index, blood glucose, lipids, leptin, and homeostatic model assessment were measured. Patients in the upper quartile of leptin levels had high values of BMI, WC, systolic and diastolic blood pressure, glucose, and HOMA index compared with patients with lower leptin levels. The prevalence of metabolic syndrome and AH increased with higher levels of leptin. Leptin positively correlated with BMI, WC, triglycerides, and glucose concentrations in patients of both sexes. According to the multivariate logistic regression analysis, elevated leptin levels increased by 30 times the risk of obesity in men, regardless of the presence of type 2 diabetes, and 17.7 times in women.ConclusionLeptin is associated with general and abdominal obesity, dyslipidemia, and insulin resistance in Kyrgyz patients.

Highlights

Leptin, an adipocytokine produced by adipose tissue, along with the traditional cardiometabolic risk factors, contributes to the development of cardiovascular complications
For evaluation of the association between leptin levels and cardiometabolic risk factors, all participants in the study were stratified into four groups based on quartiles of leptin
According to the analysis, elevated leptin levels increased by 30 times the risk of obesity in men, regardless of the presence of diabetes mellitus (DM), and 17.7 times in women

Summary

Introduction

An adipocytokine produced by adipose tissue, along with the traditional cardiometabolic risk factors, contributes to the development of cardiovascular complications. The association between obesity and cardiometabolic risk factors may be mediated by the ability of adipocytes to synthesize biologically active substances with hormonal activity [6]. One of these hormones is leptin, which was identified in 1994 and has attracted the attention of obesity researchers [7]. Leptin is a 167 amino acid protein encoded by the obesity (OB) gene and is synthesized and secreted by adipocytes. In this case, serum leptin concentrations reflect the amount of energy reserves stored in adipose tissue [8]. Leptin was shown to be associated with IR and other cardiometabolic risk factors in certain populations [10,11,12]

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