Change and significance of leptin in obstructive sleep apnea hypopnea with metabolic syndromes

Abstract

Objective To investigate the changes and implications of serum leptin levels in obstructive sleep apnea hypopnea syndrome(OSAHS) and OSAHS with metabolic syndrome (MS). Methods Seventy OSAHS men were divided into two sub-groups:OSAHS group(n=40) and OSAHS with MS group(n=30). Forty non-OSAHS men were matched with OSAHS group for body mass index(BMI) and age. Measured the height, weight, neck circumference(NC), waist, hip, fasting blood glucose(FBG), leptin, true insulin(TI), triglyceral(TG) and cholesterol(Chol). Insulin resistance was assessed by homeostasis model assessment method(HOMA-IR). Results leptin levels than non-OSAHS group(P<0.05,P<0.01). And leptin levels in OSAHS with MS group also higher than that in OSAHS group (P<0.01). Severe OSAHS group and moderate OSAHS group had significantly increased leptin levels compared with correlated positively with AHI, HOMA-IR and BMI, negatively with LSpO2. In OSAHS with MS group serum leptin levels correlated positively with AHI, HOMA-IR, BMI, NC,WHR, SBP, FBG and TG, negatively with LSpO2, multiple stepwise regression analysis identified BMI(P=0.003),HOMA-IR(P=0.024)and AHI(P=0.036) as independent significantly higher in OSAHS group than non-OSAHS control group(P<0.01); Logistic regression analysis showed that BMI(P=0.031), and leptin(P=0.064) were the independent correlates in development of the HT. Conclusions OSAHS compared with simple obesity have higher leptin level,with OSAHS progression,the conexistence of insulin resisitance and hyperleptinemia maybe involved in the pathophysiology of OSAHS combined process of MS. Key words: Obstructive sleep apnea hypopnea syndrome; Metabolic syndrome; Leptin