Abstract
BackgroundTo evaluate the association between high-sensitivity C-reactive protein (hsCRP) and erythrocyte sedimentation rate (ESR), and diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM).MethodsA cross-sectional study was conducted in 1210 patients with T2DM, among whom 265 had DKD. The severity of DKD was assessed by estimated-glomerular filtration rate (eGFR) and urinary albumin creatinine ratio (ACR). The relationship between ESR, hsCRP and DKD was analyzed by multivariate logistic analysis. The relationship between ESR and eGFR, ESR or ACR was analyzed by multivariate linear regression.ResultsESR (23.0 [12.0 ~ 41.5] mm/h versus 12.0 [7.0 ~ 22.0] mm/h, P < 0.001) and hsCRP (3.60 [2.20 ~ 7.65] versus 2.90 [1.80 ~ 5.60] mg/L mg/L, P < 0.01) values were significantly higher in patients with DKD than those without. Patients with higher ESR or hsCRP had lower eGFR and higher ACR. After adjusted for gender, age, hemoglobin, plasma proteins, HbA1c, lipid profiles, and the usage of renin-angiotensin system inhibitors, ESR but not hsCRP was independently associated with the rate and severity of DKD in patients with T2DM.ConclusionESR was independently associated with the rate and severity of DKD in patients with T2DM.
Highlights
To evaluate the association between high-sensitivity C-reactive protein and erythrocyte sedimentation rate (ESR), and diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM)
We retrospectively studied a cohort of 1210 patients with T2DM to investigate the potential relationship between DKD and the degree of systemic inflammation measured by ESR and high-sensitivity C-reactive protein (hsCRP)
A total of 1210 patients with T2DM were included in the current analysis, of whom 265 had DKD
Summary
To evaluate the association between high-sensitivity C-reactive protein (hsCRP) and erythrocyte sedimentation rate (ESR), and diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM). Type 2 diabetic mellitus (T2DM) is a chronic metabolic disorder with multiple complications, including diabetic retinopathy, diabetic neuropathy, diabetic kidney disease (DKD) as well as cardiovascular diseases [1]. DKD affects 20–40% of patients with T2DM, and is the leading cause of end-stage renal disease (ESRD) [2]. Chronic inflammation in patients with T2DM is involved in the onset and development of DKD [4]. Mounting evidences have shown that a number of molecules related to inflammation can be predictable in DKD. Gohda et al found that circulating TNF receptors were strongly associated with renal function loss in patients with DKD [7]. On ground of this, circulating inflammatory markers might be relevant to the diagnosis and prognosis of DKD [8]
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