Abstract
BackgroundDiabetic Retinopathy is one of the most common causes of blindness among adults. Microvascular complications may have common origins. The objective of the present study is to analyze the correlation between urinary IgM excretion and diabetic retinopathy based on the type of diabetes.MethodsThe present study is cross-sectional analytic and was carried out on 140 type2 diabetic patients (of which 70 patients diagnosed with retinopathy) and 76 type1 diabetic patients (of which 37 patients diagnosed with retinopathy). For every patient in each of the test groups, fasting plasma glucose, triglyceride, cholesterol, creatinin and HbA1c tests were done. The value of IgM, the albumin- to- creatinine ratio and the urine analysis test were also used to rule out the significant proteinuria of the patients. Then, IgM Index was measured using the following equation: Igm Index = Urine IgM/Urine Cr.ResultsThe level of IgM index in the diabetic patients (type1 and type2) had no significant correlation with retinopathy. Cut point = 1.49, sensitivity = 0.703 and specificity = 0.308 in type1 diabetes were used for screen retinopathy. In type1 diabetic patients, the duration of diabetes had a significant correlation with urinary protein while in type 2 diabetic patients, the diabetes duration and HbA1c were significantly correlated with retinopathy.ConclusionThe results of this study demonstrate that the level of urinary IgM in diabetic patients has no difference in those who have or lack retinopathy, but the urinary IgM level of more than 1.49 mg/dl can be considered as a cut point in type1 diabetic patients to screen retinopathy.
Highlights
Diabetic Retinopathy is one of the most common causes of blindness among adults
The type and duration of diabetes, age, sex, glycemic control, systemic hypertension,body mass index, smoking, and serum lipid and microalbuminuria are all associated with the progress of diabetic retinopathy [6,7,8,9,10]
The objective is to verify the correlation between urinary Immunoglubulin M (IgM) excretion and diabetic retinopathy based on the type of diabetes
Summary
Diabetic Retinopathy is one of the most common causes of blindness among adults. The global incidence of diabetes mellitus increased from 30 million cases in 1985 to 285 million in 2010. In Iran as a developing country, about 6 % of the population suffers from type diabetes and its complications. Diabetic retinopathy is one of the microvascular complications of diabetes and is one of the most common reasons for blindness among 20 to 74 year-old adults [4, 5]. The type and duration of diabetes, age, sex, glycemic control, systemic hypertension,body mass index, smoking, and serum lipid and microalbuminuria are all associated with the progress of diabetic retinopathy [6,7,8,9,10]
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