Abstract
BackgroundThyroid autoimmunity(TAI) is the most prevalent autoimmune condition in women of fertile age. There are increasing data regarding the association of thyroid dysfunction and thyroid autoimmunity with adverse pregnancy outcomes but there is no consensus regarding infertility and TPOAb positivity; thus we aimed to evaluate the association between thyroid TPOAb positivity and infertility in females and males in a population-based study (TTS).MethodsCross-sectional study of 3197 female and male participants in Tehran Thyroid Study (TTS) at the framework of the Tehran Lipid and Glucose Study (TLGS). Data included biochemical measurements and a self-administered questionnaire.ResultsA total of 12,823 cases in phase 4, 3719 cases (2108 female and 1611 male) were analyzed. The mean TSH of the infertile female and male was 2.52 ± 2.68 μIU/ml and 3.24 ± 10.26 μIU/ml respectively. The TPO median(IQR) of women with and without a history of infertility were 6.05 (3.30–13.96)and 6.04 (3.17–11.15);(P = 0.613), they were 5.08 (3.20–125.68) and 5.31 (3.93–125.68);(P = 0.490) in male participants, respectively. Results of crude and adjusted logistic regression analysis of the development of infertility by thyroid function and TPOAb, except for fT4 in male subjects, depicted no association between infertility and other variables in both crude and adjusted models.ConclusionBased on the result, thyroid autoimmunity was not associated with infertility in both females and males.
Highlights
Thyroid autoimmunity(TAI) is the most prevalent autoimmune condition in women of fertile age
It has been shown that except for free T4 (fT4) in male participants, there was no association between infertility and other thyroid function tests in both crude and adjusted models (Table 3; it has been shown that the odds ratio of male infertility was increased by 0.189 95% CI (0.056, 0.637), with each unit increase in Ft4; the results remained statistically significant after multiple adjustment by Age, education, BMI, Smoking, Systolic&Diastolic BP, Fasting blood Sugar (FBS) (0.26595% CI (0.075, 0.940), p = 0.040
Linear regression analysis revealed no association between time to pregnancy, the number of abortions and parity with thyroidstimulating hormone (TSH),fT4 and thyroid peroxidase antibody (TPOAb) positivity in women (Table 4); we found no association between infertility with TSH,fT4 and TPOAb positivity (Table 4)
Summary
Thyroid autoimmunity(TAI) is the most prevalent autoimmune condition in women of fertile age. There are increasing data regarding the association of thyroid dysfunction and thyroid autoimmunity with adverse pregnancy outcomes but there is no consensus regarding infertility and TPOAb positivity; we aimed to evaluate the association between thyroid TPOAb positivity and infertility in females and males in a populationbased study (TTS). TAI is the most prevalent autoimmune condition in women of fertile age [2]. There is increasing data regarding the association of thyroid dysfunction and thyroid autoimmunity with adverse pregnancy outcomes such as recurrent miscarriage and recurrent embryo implantation failure [4,5,6]. There are few population-based studies to reveal this association [13]
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