The association between spontaneous preterm birth and maternal hypertension in the fifth decade of life: a retrospective case-control study.

Abstract

To investigate whether a history of spontaneous preterm birth (SPTB) predisposes to maternal hypertension. Retrospective case-control study. Two affiliated university medical hospitals in Amsterdam, the Netherlands. We included 350 women with a history of SPTB between 22 and 36+6 weeks and 166 women with a history of a term birth. Women with pregnancy complications that are known to be associated with cardiovascular disease were excluded. Both groups underwent cardiovascular risk assessment 9-16 years after pregnancy. We performed a subgroup analysis based upon the severity of SPTB. Hypertension. Secondary outcomes - metabolic syndrome, mean blood pressure, anthropometrics, blood and urine sampling, Framingham Risk Score and Systematic Coronary Risk Evaluation. A history of SPTB was significantly associated with hypertension; adjusted odds ratio 1.60 (95% confidence interval 1.04-2.46, p=0.033). Abdominal obesity was more often diagnosed after SPTB (n=163, 46.6% versus n=54, 32.5%, p=0.003) and was more pronounced with more severe preterm birth (p=0.002). The presence of hypertension 9-16 years after pregnancy was statistically significantly higher among women with a history of SPTB than among women with a history of uncomplicated term birth. Women with a history of SPTB were more often diagnosed with abdominal obesity, especially those with a history of extreme preterm birth.