Abstract
Objective To explore the relationship between single nucleotide polymorphism analysis of a novel tryptophan hydroxylase isoform (TPH2) gene rs11178997 and depression, and suicidal behavior. Methods The specimens of peripheral blood were collected from Chinese Northern 300 depression and 300 controls. The amplification of TPH2 gene rs11178997 was executed by realtime-polymerase chain reaction (realtime-PCR), and analyzed by directed sequencing. And the association between the polymorphisms of TPH2 gene and depression and suicidal behavior was analyzed with SPSS 17.0. Results The genotypic frequencies of the SNPs did not deviate from Hardy-Weinberg equilibrium both in patient and control groups (P>0.05). Compared with control group, significant difference of genotypes and alleles of TPH2 gene rs11178997 single nucleotide polymorphism had been found in patient group (75.7% vs 39.7%, 6.0% vs 1.3%, 18.3%vs 1.3%; P 0.05). Conclusion TPH2 gene rs4570625 single nucleotide polymorphisms have association with the susceptibility of depression. Key words: Depression; Suicidal behavior; TPH2 gene; Single nucleotide polymorphism
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