Association of tryptophan hydroxylase-2 gene and family environment with antisocial personality disorder

Abstract

objective To study the association of tryptophan hydroxylase 2(TPH2)gene polymorphism and family environment with antisocial personality disorder(ASPD)in Chinese Han population.Methods The single nucleotide polymorphism(SNPs)of TPH2,rs4290270 and rs7305115 were analyzed by PCR-RFLP genotyping assay in 117 ASPD patients and 142 healthy controls.The family Environment Scale-Chinese Version(FES-CV)was used to evaluate the family environment of all subjects.Results There were no significant differences between ASPD and controls in genotype and allele frequencies of rs4290270 and rs7305115.The distributions of TA haplotype was significantly more frequent in patients than in controls[odds ratio(OR)1.865,95%confidence interval(CI)1.135-3.065,P<0.05].Interactions between genetic and environmental(G×E)revealed that expressiveness and moralreligious emphasis increased the risk of ASPD in the presence of TA haplotype[OR=1.122,95%CI 1.043-1.206;OR=1.080,95%CI 1.010-1.155,P<0.05].Conclusion The results suggest that TA haplotype might be with higher susceptibility for ASPD and adversity family environments might increase the risk of ASPD in ones with risk haplotype. Key words: Antisocial personality disorder; Haplotype; Polymorphism,restriction fragment length; Tryptophan hydroxylase 2 gene; Family environment