Abstract
Coronary artery calcium score (CACS) is a useful method for predicting coronary artery disease in asymptomatic adults. In this study, we investigated the association between prolonged sedentary time and CACS. A cohort study was conducted in 14949 men with negative CACS (CACS = 0) at baseline who were followed up at least once. Sedentary time was categorized into < 7, 7–8, and ≥ 9 h/day. CACS was calculated by cardiac tomography. During 60,112.1 person-years of follow-up, 569 participants developed positive CACS. The multivariable adjusted hazard ratios (95% confidence intervals) for incident positive CACS comparing sedentary times of 7–8 h/day and ≥ 9 h/day to sedentary time of < 7 h/day were 1.25 (0.97–1.62) and 1.28 (1.03–1.59), respectively. This association was more strongly observed in the non-obese group (BMI < 25 kg/m2). In contrast, in the obese group (BMI ≥ 25 kg/m2), there was no significant association between sedentary time and incidence of positive CACS. Prolonged sedentary time was significantly associated with incidence of positive CACS in the study. CACS is also an effective screening tool for predicting future cardiovascular events in asymptomatic patients. Therefore, CACS can be an effective screening method for predicting coronary artery diseases in people with prolonged sedentary time, especially in metabolically healthy people.
Highlights
Coronary artery calcium score (CACS) is a useful method for predicting coronary artery disease in asymptomatic adults
We investigated the association between sedentary time and CACS and analyzed the effect of prolonged sedentary time on coronary artery disease
In a multivariate model adjusting for age, alcohol intake, smoking status, regular exercise, Body mass index (BMI), systolic BP, glucose, LDL-C, triglycerides, medication for dyslipidemia, and high-sensitivity C-reactive protein (hsCRP), the adjusted hazard ratios (HRs) for incident positive CACS comparing sedentary time 7–8 and ≥ 9 h/ day to the sedentary time of < 7 h/day were 1.25 (0.97–1.62) and 1.28 (1.03–1.59), respectively, and there was a significant association between sedentary time and incidence of positive CACS (p for trend = 0.036)
Summary
Coronary artery calcium score (CACS) is a useful method for predicting coronary artery disease in asymptomatic adults. The multivariable adjusted hazard ratios (95% confidence intervals) for incident positive CACS comparing sedentary times of 7–8 h/day and ≥ 9 h/day to sedentary time of < 7 h/day were 1.25 (0.97–1.62) and 1.28 (1.03–1.59), respectively This association was more strongly observed in the non-obese group (BMI < 25 kg/m2). CACS can be an effective screening method for predicting coronary artery diseases in people with prolonged sedentary time, especially in metabolically healthy people. According to a 6-year prospective multicenter study[7], there was no significant difference in the diagnosis and prediction of future cardiovascular events in CACS evaluation compared to coronary computed tomographic angiography in asymptomatic adults. We investigated the association between sedentary time and CACS and analyzed the effect of prolonged sedentary time on coronary artery disease. We conducted a large-scale study in a relatively healthy adult male group using a cohort established from regular health screening data
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