Abstract
A relationship between nonalcoholic fatty liver disease (NAFLD) and sarcopenia has been suggested. The aim of this study was to evaluate the association between NAFLD and skeletal muscle mass measured by computed tomography (CT). The clinical records of individuals visiting our center for a routine health check-up who underwent abdominal ultrasonography and abdominal CT scanning were retrospectively reviewed. Sarcopenia was diagnosed according to body mass index (BMI)-adjusted skeletal muscle mass, which was measured by CT (CT-measured skeletal muscle index (SMICT)). Of the 1828 subjects (1121 males; mean age 54.9 ± 9.5 years), 487 (26.6%) were obese (BMI ≥ 25 kg/m2), and 454 (24.8%) had low muscle mass. Sarcopenic subjects had a significantly higher prevalence of NAFLD than nonsarcopenic subjects, regardless of obesity (35.9% vs. 26.8%, p = 0.004 in the nonobese group; 76.6% vs. 63.0%, p = 0.003 in the obese group). Sarcopenia was significantly associated with the risk of NAFLD (adjusted odds ratio (OR) (95% confidence interval (CI)), 1.51 (1.15–1.99)), and the risk of NAFLD increased with increasing severity of sarcopenia (adjusted OR (95% CI), 1.45 (1.09–1.92) vs. 2.51 (1.16–5.56), mild vs. severe sarcopenia, respectively). When the risk of NAFLD was analyzed according to the SMICT quartiles, the adjusted OR and 95% CI for the lowest muscle mass quartile compared to the highest were 1.78 (1.17–2.72) in males and 2.39 (1.13–5.37) in females. Low skeletal muscle mass, which was precisely measured by CT, is independently associated with NAFLD, suggesting that sarcopenia is a risk factor for NAFLD.
Highlights
A progressive decrease in muscle mass is a common body composition change associated with aging, and this change was described as sarcopenia by Rosenberg in 1989 [1]
The aim of this study was to evaluate the association between Nonalcoholic fatty liver disease (NAFLD) and muscle mass, which was precisely measured by computed tomography (CT)
To the best of our knowledge, this is the first study on the relationship between NAFLD and muscle mass measured by CT scanning
Summary
A progressive decrease in muscle mass is a common body composition change associated with aging, and this change was described as sarcopenia by Rosenberg in 1989 [1]. Many studies have examined the association between sarcopenia and related diseases, such as metabolic syndrome (MS), cardiovascular disease, and the risk of death in the elderly [2,3,4,5,6]. Recent studies have reported a relationship between sarcopenia and NAFLD, and several mechanisms have been suggested [10,11]. The most important pathogenesis connecting sarcopenia and NAFLD is insulin resistance [12,13]. Lee et al reported that sarcopenia is associated with NAFLD independent of obesity and insulin resistance, suggesting that sarcopenia is an independent risk factor for NAFLD [14]
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