The association between hypertriglyceridemic-waist phenotype and chronic kidney disease: a cohort study and meta-analysis

Dezhong Chen,Huimin Sun,Ciyong Lu,Weiqing Chen,Vivian Yawei Guo

doi:10.1038/s41598-022-05806-7

Dezhong Chen, Huimin Sun + Show 3 more

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https://doi.org/10.1038/s41598-022-05806-7

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Journal: Scientific Reports	Publication Date: Feb 4, 2022
Citations: 10	License type: open-access

Affiliation: Sun Yat-sen University

Abstract

Evidence on the association between hypertriglyceridemic-waist phenotype (HTGW) and chronic kidney disease (CKD) is limited and inconsistent. We aimed to explore such association among 7406 Chinese aged ≥ 45 years in a cohort setting, followed by a meta-analysis. Participants were categorized into four phenotypes: NTNW (normal triglycerides and normal waist circumference), NTGW (isolated enlarged waist circumference), HTNW (isolated high triglycerides), and HTGW (high triglycerides and enlarged waist circumference). We used multivariate logistic regression to determine the association between different phenotypes and risk of CKD in the cohort study. For meta-analysis, we searched relevant studies from Embase, Medline, PubMed, and Web of Science from dataset inception up to May 1, 2021. A random-effect model was used to estimate the pooled effect and I2 statistic was applied to evaluate heterogeneity. In the cohort study, compared to the NTNW phenotype, HTGW (OR 1.82, 95% CI 1.32 to 2.51, p < 0.01) and NTGW (OR 1.48, 95% CI 1.13 to 1.94, p = 0.004) were significantly associated with CKD risk after 4 years follow-up, but not for the HTNW phenotype. The meta-analysis also showed a positive association between HTGW phenotype and CKD risk (pooled OR 1.53, 95% CI 1.31 to 1.79, I2 = 62.4%). Assessment of triglyceridemic-waist phenotypes might help to identify individuals with high-risk of developing CKD.

Highlights

Evidence on the association between hypertriglyceridemic-waist phenotype (HTGW) and chronic kidney disease (CKD) is limited and inconsistent
A cross-sectional study in China showed that the significant association between HTGW and CKD was only present in males, but not in females[17]
We further found that current drinking status was as significant effect modifier in the association between triglyceridemic-waist phenotypes and risk of CKD, while age, sex, Body mass index (BMI), history of diabetes mellitus (DM) or hypertension were not

Summary

Introduction

Evidence on the association between hypertriglyceridemic-waist phenotype (HTGW) and chronic kidney disease (CKD) is limited and inconsistent. The meta-analysis showed a positive association between HTGW phenotype and CKD risk (pooled OR 1.53, 95% CI 1.31 to 1.79, I2 = 62.4%). A meta-analysis of 21 cohort studies further confirmed that elevated waist circumference was associated with higher risk of declines in estimated glomerular filtration rate (eGFR), an indicator of kidney function that bears great importance in clinical decision-making[10]. A cross-sectional study with 1,828 adults aged between 18 and 75 years has found that the risk of impaired renal function was significantly higher in participants with HTGW compared to those with normal waist circumference and normal triglyceride levels[14]. A cross-sectional study in China showed that the significant association between HTGW and CKD was only present in males, but not in females[17]. A cross-sectional study further demonstrated that HTGW was linked to mildly and moderately reduced eGFR (eGFR between 30 and 89 mL/min/1.73 m 2), but not severely reduced eGFR (eGFR between 15 and 29 mL/ min/1.73 m2)[16]

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