Abstract
BackgroundSerum uric acid (UA) has been reported as a risk factor for type 2 diabetes mellitus (T2DM). However, whether serum UA is associated with insulin resistance and insulin secretion, and the effect of gender on it in the case of the existed association, both remain undefined.MethodsA cross-sectional study was designed and performed, which enrolled a total of 403 newly diagnosed T2DM patients (mean age, 50.21 ± 13.34 years (62.5% males)). Clinical characteristics and islet function indexes of all participants were analyzed based on gender-specific tertiles of serum UA levels. In addition, multiple linear regression analysis was conducted to investigate covariates associated with islet function indexes.ResultsThe mean levels of serum UA were 331.05 μmol/L (interquartile range (IQR): 60.6, 400.9 μmol/L) and 267.9 μmol/L (IQR: 204.7, 331.9 μmol/L) in men and women, respectively. The values of insulin secretion indexes involving AUCins30/glu30, AUCins120/glu120 and total insulin disposition index (DI120) in females were significantly higher than those in males. Apart from the homeostasis model assessment insulin resistance of men, serum UA was positively associated with insulin secretion and insulin resistance indexes both in men and women. Multivariable linear regression analysis showed serum UA exerted an independent impact on insulin secretion in females, but not on insulin resistance. In males, islet function was simultaneously affected by serum UA age, body mass index (BMI), and serum lipids.ConclusionSerum UA harbored a positive correlation with insulin secretion and insulin resistance indexes in newly diagnosed T2DM patients, which was influenced by gender, BMI, serum lipids. Hence, serum UA may be considered as a predictor for islet function in clinical practice.
Highlights
Type 2 diabetes mellitus (T2DM) is one of the most prevalent chronic diseases at present, affecting 415 million adults worldwide (Ogurtsova et al, 2017)
Serum uric acid (UA) levels and values of body mass index (BMI), DBP, FBG, blood urea nitrogen (BUN), and serum creatinine (Scr) were significantly higher in men than those in women
UA, uric acid; BMI, body mass index. In this population-based study of newly diagnosed type 2 diabetes mellitus (T2DM) in Chinese participants, we found that the values of AUCins30/glu30 and AUCins120/glu120 were higher in females than in males
Summary
Type 2 diabetes mellitus (T2DM) is one of the most prevalent chronic diseases at present, affecting 415 million adults worldwide (Ogurtsova et al, 2017). Serum uric acid (UA) has been reported as a risk factor for type 2 diabetes mellitus (T2DM). Clinical characteristics and islet function indexes of all participants were analyzed based on gender-specific tertiles of serum UA levels. Apart from the homeostasis model assessment insulin resistance of men, serum UA was positively associated with insulin secretion and insulin resistance indexes both in men and women. Multivariable linear regression analysis showed serum UA exerted an independent impact on insulin secretion in females, but not on insulin resistance. Islet function was simultaneously affected by serum UA age, body mass index (BMI), and serum lipids. Conclusion: Serum UA harbored a positive correlation with insulin secretion and insulin resistance indexes in newly diagnosed T2DM patients, which was influenced by gender, BMI, serum lipids. Serum UA may be considered as a predictor for islet function in clinical practice
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