The Association between Anthropometry Indices and Serum Concentrations of Gamma-Glutamyl Transferase, Alkaline Phosphatase, Alanine Aminotransferase, and Aspartate Aminotransferase.

Sahar Sobhani,Maryam Alinezhad-Namaghi,Sara Raji,Elahe Ebrahimi Miandehi,Reihaneh Aryan,Mina Akbarirad,Seyyed Reza Sobhani,Ali Abbara

doi:10.1155/2021/2365399

Abstract

Background Nowadays, metabolic syndrome (MetS) has become a great public health crisis that threatens too many lives worldwide. Many previous studies have been investigated the association between MetS and anthropometric indices. This study is aimed at investigating the association between anthropometric indices with gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), alanine aminotransferase (ALT), and aspartate aminotransferase (AST). We were using data from a large population-based cohort of seemingly healthy women and men. Methods A total of 7216 participants were included in this study. The serum levels of GGT, ALP, ALT, and AST with bioimpedance measures were obtained at the time of enrollment. Multiple regression analysis was performed to assess the relationship between anthropometric indices and serum levels of the aforementioned laboratory tests. Results Serum levels of GGT, ALP, ALT, and AST significantly correlated with body mass index (BMI). Only ALP had a significant association with visceral fat area (VFA). AST, ALT, and ALP levels had a positive correlation with 50 kHz whole-body phase. Conclusion From the findings of this study, body mass index consistently appeared a good predictor of elevated hepatic enzymes and triglycerides. Thus, it can be helpful in clinical settings to identify patients at risk of nonalcoholic fatty liver disease, which is closely related to metabolic syndrome.

Highlights

Nowadays, metabolic syndrome (MetS) has become a great public health crisis that threatens too many lives worldwide [1]
Extensive epidemiological studies on the Iranian, Chinese, and Qatari adult populations demonstrated that waist circumference (WC) was highly associated with the MetS as its best indicator, while waist-to-height ratio (WHtR) was considered the best anthropometric index for MetS prediction in Japanese and Italian adults [5, 6]
We found that only serum levels of alkaline phosphatase (ALP) had a significant correlation with visceral fat area (VFA), and the other laboratory test showed no significant correlation with this index

Summary

Introduction

Metabolic syndrome (MetS) has become a great public health crisis that threatens too many lives worldwide [1] This metabolic disorder occurs when at least three of the following medical conditions are being clustered: abdominal obesity, hypertriglyceridemia, low serum high-density lipoprotein (HDL) level, hyperglycemia, and hypertension [2]. This study is aimed at investigating the association between anthropometric indices with gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), alanine aminotransferase (ALT), and aspartate aminotransferase (AST). Serum levels of GGT, ALP, ALT, and AST significantly correlated with body mass index (BMI). From the findings of this study, body mass index consistently appeared a good predictor of elevated hepatic enzymes and triglycerides It can be helpful in clinical settings to identify patients at risk of nonalcoholic fatty liver disease, which is closely related to metabolic syndrome

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Discussion

Conclusion