Abstract
Background. Recently published guidelines emphasize that detection of any subclinical target organ damage in hypertensive subjects should be regarded as a sign of high cardiovascular risk.Aim. To assess the ability of conventional multivariable cardiovascular disease risk prediction tools and high-sensitivity C-reactive protein (hs-CRP) to identify hypertensive subjects with target organ damage.Methods. Ankle-brachial index (ABI), estimated glomerular filtration rate (eGFR), electrocardiographically determined left ventricular hypertrophy (ECG-LVH), and base-line variables were measured in hypertensive subjects aged 45–70 years without established cardiovascular or renal disease or known diabetes.Results. Of the 495 subjects, 123 (24.8% (95% CI 21.1–28.9)) had ABI <1.00, 81 (16.4% (95% CI 13.2–19.9)) had ECG-LVH, and 41 (8.3% (95% CI 6.0–11.1)) had eGFR <60 mL/min/1.73 m2. In patients with SCORE <5% or Framingham risk <20%, any sign of target organ damage was found in 46% and 49% of patients, respectively.Conclusion. Assessment of ECG-LVH, ABI, and eGFR reclassifies a significant number of hypertensive patients to the high-risk category as compared to SCORE and Framingham risk prediction tools only.
Published Version
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