Abstract
The construction of oral mucosa infection model in vitro is conducive to exploring the pathogenesis and prevention strategies of oral infectious diseases of oral mucosa. The organotypic oral mucosal infection model is based on the tissue-engineered oral mucosa, which is cocultured with the extraction of pathogens, planktonic microorganisms, biofilm or saliva, to mimic the interactions between the oral microbiome and the oral mucosa of the host. In recent years, researchers have used this technology to study the role of microbes in the development and pathogenesis of oral mucosal diseases and periodontal diseases. This article reviews the construction, recent advances and perspectives of the organotypic oral mucosa infection model. Key words: Tissue engineering; Biofilms; Mouth mucosa; Infection; Three-dimensional cultures
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