The application value of HR-HPV detection combined with TCT in the screening of cervical cancer and precancerous lesions

Abstract

Objective To explore the diagnostic value of HR-HPV combined with TCT in the diagnosis of cervical cancer and precancerous lesion. Methods 1 198 cervical specimens were selected for the study.The results of HR-HPV detection and TCT detection were analyzed, with the pathological results as the gold standard, the diagnostic value of HR-HPV and TCT in the diagnosis of cervical cancer and precancerous lesion were discussed. Results With increasing pathological grade, TCT positive rate increased gradually, there was a correlation between them(r=0.629, P<0.05). With increasing pathological grade, HR-HPV positive rate increased gradually, there was a correlation between them(r=0.684, P<0.05). The sensitivity of HR-HPV combined with TCT in the differential diagnosis of cervical cancer, precancerous lesions was 100.00%, specificity was 79.64%, missed diagnosis rate was 0.00%, the misdiagnosis rate was 20.36%. Conclusion HR-HPV combined with TCT examination has high clinical value in the diagnosis of cervical cancer and precancerous lesions. Key words: Human papillomavirus; Thinprep cytology test; Uterine cervical neoplasms; Precancerous conditions; Multiphasic screening