Abstract
Background Neurological diseases represent a pressing global health concern; the World Health Organization reports that neurological conditions rank as the second leading cause of death worldwide. In the last quarter century, we have witnessed a remarkable 36% surge in global neurological mortality rates. Several factors, including oxidative stress, genetic variability, natural aging process, inflammation, hypertension, diabetes, infections, vitamin deficiencies, metabolic imbalances, chemical exposures, endocrine disorders, and dietary supplements, are implicated in the initiation and progression of various neurological diseases. Purpose This comprehensive review aims to shed light on the neuroprotective attributes of distinct Ficus and their phytoconstituents that have been harnessed for treating neurological diseases and demonstrating neuroprotective effects. Methods A literature search was conducted to obtain information about the study of neurological disease and their treatment using database and search engine like Google Scholar, Research gate, monograph, reference book, SciFinder, PubMed/Medline, Scopus, and Science Direct. Results Ficus species have exhibited remarkable neuroprotective qualities through various mechanisms of action. Moreover, these plants contain a diversity of bioactive such as flavonoids, polyphenols, terpenoids, tannins, alkaloids, glycosides, sterols, and vitamins that proven effective in enhancing memory, reducing anxiety, increasing neurotransmitter levels, mitigating neurodegeneration, and playing pivotal roles in neuroprotection. Conclusion This review consolidates the promising potential of Ficus species in the treatment of neurological diseases, paving the way for future scientific research in the development of novel herbal neuroprotective medications.
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