Linarin Protects against Cisplatin-induced Nephrotoxicity via Subsiding Proinflammatory and Oxidative Stress Biomarkers in Male Wistar Rats

Abstract

Background One of the most effective anticancer medications for treating a range of cancers is cisplatin (Cis). Its use is limited because of its nephrotoxicity. Purpose This study aims to evaluate the role of linarin (LIN) in protecting rats from Cis-induced nephrotoxicity. Methods The animals were split up into four groups: Group I consisted of control animals; group II consisted of Cis-treated animals; group III consisted of Cis-treated animals that received a 25 mg/kg dosage of LIN; group IV consisted of Cis-treated animals that received a 50 mg/kg dose of LIN. We measured the kidney and body weights of each experimental group. Blood samples were taken to measure the blood urea nitrogen (BUN) and Cr levels in the test animals. To further evaluate the effects of LIN therapy in a dose-dependent manner, an investigation of antioxidant enzymes, oxidative stress indicators, plasma sodium and potassium levels, inflammatory markers, and histopathology was conducted. Results We found that giving LIN to Cis-treated rats helped to enhance renal function. The animals’ body weight, histopathological conditions, and amount of antioxidant enzymes were all markedly elevated by LIN in the animals. Additionally, it decreased kidney weight, BUN and Cr levels, oxidative stress indicators, and inflammatory markers. Conclusion Therefore, we conclude that LIN can be utilized to protect the kidneys from damage caused by Cis therapy. Nurses can promote well-being and recovery in patients at risk of Cis-induced nephrotoxicity by encouraging gentle physical activities and providing emotional and psychological support, leveraging LIN’s protective effects.