Abstract
Chitosan (CS) is a natural polymer with a positive charge, a deacetylated derivative of chitin. Chitosan nanostructures (nano-CS) have received increasing interest due to their potential applications and remarkable properties. They offer advantages in stomatology due to their excellent biocompatibility, their antibacterial properties, and their biodegradability. Nano-CSs can be applied as drug carriers for soft tissue diseases, bone tissue engineering and dental hard tissue remineralization; furthermore, they have been used in endodontics due to their antibacterial properties; and, finally, nano-CS can improve the adhesion and mechanical properties of dental-restorative materials due to their physical blend and chemical combinations. In this review, recent developments in the application of nano-CS for stomatology are summarized, with an emphasis on nano-CS’s performance characteristics in different application fields. Moreover, the challenges posed by and the future trends in its application are assessed.
Highlights
10 SeptemberNano-CS has the ability to stably increase the release of NaF in an acidic environment with a pH of 5 to 7 [1,20]
This review focuses on the preparation of CS nanoparticles and the antibacterial properties of nano-CS
Intrafibrillar mineralization caused by Non-collagen proteins (NCPs) is essential to sential to increase the mechanical properties of dentin and prevent COL from inhibiting increase the mechanical properties of dentin and prevent COL from inhibiting hydrolytic hydrolytic degradation degradation
Summary
Nano-CS has the ability to stably increase the release of NaF in an acidic environment with a pH of 5 to 7 [1,20]. Drug carriers, significantly increasing the bioavai drugs and reducing their toxicity side by effects. Nano-CS may have many effects in local oral administration, such as targeted adhesion toxicity [22].slow drug release, resistance to acidic oral environments, the to the surface of oral tissues, improvement of drug bioavailability, and so on. Drugs such as anionic trichloroacetic acid (TCA) and epidermal growth factor (EGF) can be loaded through ionic bonds (shown in Figure 3) [17,26].
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