Abstract
Enterosorbents and prebiotics are included in treatment protocols for somatic disorders in chronic alcohol intoxication. Considering on relevant properties of pectin, the purpose of the study was to investigate its effect on biochemical and hematological parameters of experimental animals in chronic alcoholic intoxication. The study was conducted on 30 white outbred rats (males) weighing 180-200 g, which injected 30% ethanol into the stomach (control), animals in experimental groups after 30 minutes, got apple pectin at a dose of 0.2 g/100 g of body weight and reference preparations — activated charcoal and silicon dioxide — by 0.25 g and 0.05 g, respectively for 11 days. The statistical analysis was performed by Microsoft Exel and Statistica 5.5 (Multiple Regression) software using variation statistics methods. Research results. Changes in lipid metabolism were manifested by an increase in serum cholesterol of alcoholic animals without treatment by 29.8% compared with intact (p˂0.05). The use of pectin and reference drugs significantly reduced cholesterol levels. In the group with the use of pectin, this indicator was 36% lower, activated charcoal — by 19%, silicon dioxide — by 26.4% (p˂0,05) compared to untreated animals, at the same time, practically did not differ from intact animals. The level of triacylglycerols increased in all experimental groups and, although, it significantly differed from the intact, at the same time, it was essentially lower in all groups of treated animals than in non-treated ones (p˂0.05). A normalizing effect of pectin and silicon dioxide on the number of erythrocytes and hemoglobin levels comparing to alcoholated and treated activated charcoal animals also were shown (p˂0.05). The apple pectin curative effect on lipid and protein metabolism, as well as on the content of erythrocytes and hemoglobin in the blood of animals with chronic alcohol intoxication, practically equaled to standard enterosorbents, and on some indicators exceeds their effect, which may also be due to partial neutralization of ethanol.
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