Abstract
Background:Hepatocellular carcinoma (HCC) is the sixth most common type of cancer. Prognosis of HCC remains unsatisfactory. Therefore, developing new therapeutic modalities is still mandatory. Tumor biotherapy is a novel concept developed as a therapeutic strategy for cancer treatment. There is a similarity between the regulatory mechanism of Trichinella spiralis nurse cell formation and tumor cell apoptosis signal regulation. Objectives:Induction of apoptosis by T. spiralis can represent a new strategy for tumor treatment. Methods:Experimental animals were divided in four groups; negative control (GI), T. spiralis infected (GII), induced HCC (GIII) and HCC then infected with T. spiralis (GIV). The apoptotic effect of T. spiralis infection was assessed by histopathological and immunohistochemical staining of B-cell lymphoma 2 (Bcl-2). Results:We found higher survival rate of rats and decreased weight of their livers with no nodules in HCC- T. spiralis group as compared to HCC group. Improvement of the dysplastic changes and increased apoptotic bodies which was confirmed by decreased expression of Bcl-2 reported in HCC- T. spiralis group. Conclusion: Trichinella-induced apoptosis can be a contributing mechanism of the anti-tumor effect of T. spiralis infection. Our results showed a certain level of decreased progression of the tumor in HCC-T. spiralis group as indicated by increased rate of apoptosis and subsequently had a positive impact on the survival of rats.
Highlights
Hepatocellular carcinoma (HCC) is the sixth most common type of cancer with about 9.2% of all cancer-related mortalities (Ferlay et al, 2010)
Experimental animals were divided in four groups; negative control (GI), T. spiralis infected (GII), induced HCC (GIII) and HCC infected with T. spiralis (GIV)
Our results showed a certain level of decreased progression of the tumor in HCC-T. spiralis group as indicated by increased rate of apoptosis and subsequently had a positive impact on the survival of rats
Summary
Hepatocellular carcinoma (HCC) is the sixth most common type of cancer with about 9.2% of all cancer-related mortalities (Ferlay et al, 2010). Tumor biotherapy is a novel concept developed as a therapeutic strategy for cancer treatment aiming to suppress or eliminate tumors using biological agents. It includes the use of cytokines, monoclonal antibody, growth and differentiation factors, cancer gene therapy, and anti-tumor bioactive materials (Oldham and Dillman, 2009; Torre et al, 2015). Tumor biotherapy is a novel concept developed as a therapeutic strategy for cancer treatment. Our results showed a certain level of decreased progression of the tumor in HCC-T. spiralis group as indicated by increased rate of apoptosis and subsequently had a positive impact on the survival of rats
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