Abstract
The Antioxidant Effects of the Ethanolic Extract of Binahong Leaves Unilateral Ureteral Obstruction Rat Model
Highlights
Kidney disease is a disease that affects the world's population
The results showed that ureteral obstruction (UUO) produced high MDA levels, whereas Superoxide Dismutase (SOD) activity and catalase activity were decreased compared with the Sham group
acute kidney injury (AKI) can develop into a chronic disorder (CKD), a condition characterized by organ remodeling and fibrosis.[3]
Summary
Kidney disease is a disease that affects the world's population. In 2010, it was known that 2.62 million people received dialysis in all world. The ethanolic extract of binahong leaves (Anredera cordifolia (Ten.) Steenis) has a flavonoid content, quercetin, a protective free radical effect. This study aims to determine the impact of binahong leaves against chronic kidney damage in Sprague Dawley rats. Methods: To this end, we developed a chronic kidney injury animal model by Unilateral Ureteral Obstruction (UUO) method. Results: The results showed that UUO produced high MDA levels, whereas SOD activity and catalase activity were decreased compared with the Sham group. Administration of binahong extracts could reduce the MDA amount and increased the SOD and catalase activity. Conclusion: Binahong leaves extracts showed antioxidant activity to prevent kidney injury in UUO model rats.
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