Abstract
The present study was conducted to evaluate the analgesic potential of the new triamilide macrolide antibiotic, tulathromycin, at 20 and 40 mg/kg of body weight (BW), subcutaneously against acute pain in mice. Acute pain was induced either chemically (using acetic acid-induced writhing and formalin-induced pain tests) or thermally (using hot-plate, and tail-flick tests). In the acetic acid-induced writhing test, tulathromycin induced a dose-dependent and significant decrease in the number of writhes compared with the control group. In the late phase of the formalin test, a significant decline in hind paw licking time compared with the control group was observed. In the hot-plate and tail-flick tests, tulathromycin caused a dose-dependent and significant prolongation of latency of nociceptive response to heat stimuli, compared with the control group. These findings may indicate that tulathromycin possesses significant peripheral and central analgesic potentials that may be valuable in symptomatic relief of pain, in addition to its well-established antibacterial effect.
Highlights
IntroductionPain is an established consequence in almost all illnesses
We found that tulathromycin ameliorated both chemically and thermally induced acute pain in mice
The reduced the number of writhing reflexes in the acetic acid-induced writhing test and the decrease of the time of paw-licking in the formalin test indicates that tulathromycin has the potential to alleviate the chemically induced acute pain, whether of cutaneous or visceral origin
Summary
Pain is an established consequence in almost all illnesses. While uncomfortable, it is a warning of disease or a threat to the body. Pain is the most common reason for physician consultation [1,2] and its control is a substantial event in remedy and comfort of patients. Nociception ( nocioception or nociperception, from Latin nocere ‘to harm or hurt’)
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