Abstract
AbstractThe pharmacological effects of Boussingaultia gracilis var. pseudobaselloides was studied against carrageenaninduced paw oedema, CCI4 and D‐galactosamine (D‐GalN) induced hepatotoxicity in rats. The water extracts of B. gracilis var. pseudobaselloides (leaf, stem, brood bud) were found to maintain significant antiinflammatory activity against carrageenan‐induced oedema. The administration of the brood bud extract (300 mg/kg) was more potent than indomethacin (10 mg/kg).Moreover, the water extracts of B. gracilis var. pseudobaselloides (leaf, stem, brood bud) significantly decreased the acute increase in serum GOT and GPT levels caused by CCI4 and D‐GalN. Histological changes such as necrosis, fatty change, ballooning degeneration, inflammatory infiltration of lymphocytes and Kupffer cells around the central vein (CCI4‐induced hepatotoxicity) and portal vein (D‐GalN induced hepatotoxicity), were simultaneously improved by the treatment with B. gracilis var. pseudobaselloides (leaf, stem, brood bud).
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