Abstract
The pharmacological effects of Boehmeria nivea and B. nivea subsp. nippononivea were studied against carrageenan-induced paw edema, acetaminophen (APAP) and D-galactosamine (D-GalN) induced hepatotoxicity in rats, respectively. Water extracts of B. nivea and B. nivea subsp. nippononivea roots were found to maintain significant antiinflammatory activity against carrageenan-induced edema. Moreover, the water extracts of B. nivea and B. nivea subsp. nippononivea significantly decreased the acute increase in serum GOT and GPT levels caused by APAP and D-GalN-intoxication. The histopathological changes of hepatic lesions caused by these hepatotoxicants were improved by treatment with B. nivea and B. nivea subsp. nippononivea, which were compared with Silymarin as a standard.
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