Abstract
Abstract : The possible role of the mineralocorticoids in the antidiuretic response to chlorothiazide therapy was investigated in diabetes insipidus and adrenalectomized dogs. Administration of sodium retaining steroids to diabetes insipidus dogs did not reproduce the urinary changes associated with chlorothazide therapy. In addition, the antidiuretic response to chlorothiazide was not altered by adrenalectomy or spironolactone ad ministration. Therefore, the presence of the sodium-retaining steroids are not essential for the antidiuretic response of chlorothiazide in diabetes insipidus.
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