Sarcoidosis with panhypopituitarism and diabetes insipidus.

Abstract

Case Reports1 December 1959SARCOIDOSIS WITH PANHYPOPITUITARISM AND DIABETES INSIPIDUSJOSEPH R. NORA, M.D., JOHN M. LEVITSKY, M.D., HYMAN J. ZIMMERMAN, M.D., F.A.C.P.JOSEPH R. NORA, M.D.Search for more papers by this author, JOHN M. LEVITSKY, M.D.Search for more papers by this author, HYMAN J. ZIMMERMAN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-51-6-1400 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPituitary insufficiency is a rare complication of sarcoidosis.1, 2 Diabetes insipidus due to infiltration of the posterior lobe of the pituitary or hypothalamus has been reported by Tillgren,3 Longcope4 and others. Anterior pituitary insufficiency has been reported even less frequently.5, 6 The coexistence of diabetes insipidus and anterior pituitary dysfunction, as reported below, is a unique complication of sarcoidosis. The patient described illustrates some of the endocrine interrelationships involved in diuresis and antidiuresis.CASE REPORTThis 38 year old Negro male steward had been in good health until one year prior to his admission to the hospital, at which time...Bibliography1. BleischRobbins VRSL: Sarcoid like granulomata of the pituitary gland; cause of pituitary insufficiency, Arch. Int. Med. 89: 877, 1952. CrossrefGoogle Scholar2. RickardsHarvey AGPW: Giant cell granuloma and other pituitary granulomata, Quart. J. Med. 23: 425, 1954. MedlineGoogle Scholar3. Tillgren J: Diabetes insipidus as a symptom of Schaumann's disease, Brit. J. Dermat. 47: 223, 1935. CrossrefGoogle Scholar4. Longcope WT: Sarcoid or Besnier-Boeck-Schaumann's disease, Frank Billings lecture, J. A. M. A. 117: 1321, 1941. CrossrefGoogle Scholar5. GlassDavis SJDS: Granuloma of the pituitary associated with panhypopituitarism, J. Clin. Endocrinol. 4: 489, 1944. CrossrefGoogle Scholar6. LongcopeFreiman WTDG: Study of sarcoidosis based on combined investigation of 160 cases including 30 autopsies from Johns Hopkins Hospital and Massachusetts General Hospital, Medicine 31: 1, 1952. CrossrefMedlineGoogle Scholar7. HickeyHare RCK: Renal excretion of chloride and water in diabetes insipidus, J. Clin. Investigation 23: 768, 1944. CrossrefMedlineGoogle Scholar8. Albert A: Procedure for routine clinical determination of urinary gonadotropin, Proc. Staff Meet., Mayo Clin. 30: 552, 1955. MedlineGoogle Scholar9. Richter CP: Experimental diabetes insipidus in relation to the anterior and posterior lobes of the pituitary, Am. J. Physiol. 110: 124, 1934. CrossrefGoogle Scholar10. DoxiadesTiliakos TM: Diabetes insipidus in association with post partum hypopituitarism, Brit. M. J. 1: 23, 1956. CrossrefMedlineGoogle Scholar11. HeinbeckerWhiteRolf PHLD: The essential lesion in experimental diabetes insipidus, Endocrinology 40: 104, 1947. CrossrefMedlineGoogle Scholar12. LipsettMacleanWestLiPearson MBJPCDMCOH: Analysis of the polyuria induced by hypophysectomy in man, J. Clin. Endocrinol. and Metabolism 16: 183, 1956. CrossrefGoogle Scholar13. Williams RH: Textbook of endocrinology, 2nd Ed., 1955, W. B. Saunders Company, Philadelphia, p. 20. Google Scholar14. IkkosLuftOlivercrona DRH: Hypophysectomy in man: effect on water excretion during first two post operative months, J. Clin. Endocrinol. and Metabolism 15: 553, 1955. CrossrefGoogle Scholar15. RobertsPitts KERF: The influence of cortisone on renal function and electrolyte excretion in the adrenalectomized dog, Endocrinology 50: 51, 1952. CrossrefMedlineGoogle Scholar16. WestonHorowitzGrossmanHanensonLeiter REHBJIBL: Decreased antidiuretic response to beta hypophamine in hyperthyroidism, J. Clin. Endocrinol. and Metabolism 16: 322, 1956. CrossrefGoogle Scholar17. HarePhillipsBradshawChambersHare KDMJGRS: The diuretic action of the thyroid in diabetes insipidus, Am. J. Physiol. 141: 187, 1944. CrossrefGoogle Scholar18. HeinbeckerWhite PHL: Hypothalamic-hypophyseal system and its relation to water balance in the dog, Am. J. Physiol. 133: 582, 1944. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Received for publication May 14, 1958.From the Medical Service, West Side Veterans Administration Hospital, Chicago, Illinois.Requests for reprints should be addressed to Hyman J. Zimmerman, M.D., Department of Medicine, The Chicago Medical School, 2755 West Fifteenth Street, Chicago 8, Illinois. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDisordered Control of Thirst in Hypothalamic-Pituitary SarcoidosisSarkoidosePartial hypopituitarism and possible hypothalamic involvement in sarcoidosisSARCOIDOSIS WITH OCULAR AND HYPOTHALAMICPITUITARY MANIFESTATIONFunktion des Hypophysenvorderlappens bei thorakaler SarkoidoseEndocrine Aspects of SarcoidosisNephrogenic Diabetes Insipidus Due to Sarcoidosis Without HypercalcemiaFRED PANITZ, JAMES H. SHINABERGER 1 December 1959Volume 51, Issue 6Page: 1400-1409KeywordsHypothalamusMedical servicesPanhypopituitarismSarcoidosisThyroid Issue Published: 1 December 1959 PDF downloadLoading ...