Abstract
Introduction: A huge reservoir of bioactive compounds exists in many species of plants, only a small percentage of which have been examined and continued to be an important source of anticancer agents. Worldwide effects are ongoing to identify new anticancer compounds from plants. With the current decline in the number of new molecular entities from the pharmaceutical industry, novel anticancer agents are being sought from traditional medicines. Objective: In the present study we investigated the efficacy of methanol extracts of Pavonia odorata, for its clonogenic inhibition on Human Breast cancer (MD-MB-231), Prostate cancer (PC-3) and Lung cancer (Calu-6) cell lines. Materials and Methods: The cytotoxic effect was evaluated by MTT assay. Results: The methanol extract of P. odorata showed significant cytotoxicity against MD-MB-231 and Calu-6, when compared to PC-3cells. Conclusion: The methanol extracts of P. odorata, showed effective cytotoxic activities in a dose dependent manner. Future work will be interesting to know the chemical composition and also better understanding the mechanism of action will help in developing it as drug for therapeutic application.
Highlights
A huge reservoir of bioactive compounds exists in many species of plants, only a small percentage of which have been examined and continued to be an important source of anticancer agents
Natural products from plants, used either alone or with combinatorial synthetic methodologies, constitute a multidisciplinary approach to the current drug productivity.[4,5]. This has opened up new fields of investigation of potential antitumor compounds, some of which are already widely used in cancer chemotherapy which act through different pathways in activation of apoptosis in cancer cells leading to cell cytotoxicity
We investigated the efficacy of methanol extracts of P. odorata, for its clonogenic inhibition on Human Breast cancer (MDMB-231), Prostate cancer (PC-3) and Lung cancer (Calu-6)
Summary
A huge reservoir of bioactive compounds exists in many species of plants, only a small percentage of which have been examined and continued to be an important source of anticancer agents. The exploration of nature as a source of new active agents is needed for discovering bioactive chemo-types from natural product for the development and novel molecular diversity of efficacious drugs. In this respect, natural products from plants, used either alone or with combinatorial synthetic methodologies, constitute a multidisciplinary approach to the current drug productivity.[4,5] This has opened up new fields of investigation of potential antitumor compounds, some of which are already widely used in cancer chemotherapy which act through different pathways in activation of apoptosis in cancer cells leading to cell cytotoxicity
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