Abstract
Purpose: This single-center retrospective study involving the data of human participants aimed to determine the antibiotic resistance rates of Pseudomonas aeruginosa strains isolated from samples collected by the microbiology laboratory for four years.
 Methods: The samples of wound, blood, tracheal aspirate, abscess, vagina, cerebrospinal fluid, sputum, and urine culture isolated from 789 patients who were hospitalized in the service, intensive care and outpatient services between 2017-2021 were evaluated retrospectively for Pseudomonas species. 
 Results: Most of culture were urine (42.7%) and sputum cultures (20.4%). Most patients applied to the service were transferred from department of chest diseases (38.6%) or from department of urology (14.3%) or palliative care unit (12.5%). The highest rates of resistances were against cefuroxime, levofloxacin and netilmicin; lowest rate of resistance was against amikacin. The resistances against aztreonam, cefepime and gentamicin significantly reduced over years (P=0.0321, 0.0038 and 0.0004, respectively) while resistances against colistin and levofloxacin considerably increased (P
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