The Antibiotic Resistance Patterns of Pseudomonas Aeruginosa Strains Isolated from Microbiological Specimens

Abstract

To determine the antibiotic resistance rates of Pseudomonas aeruginosa strains isolated from samples collected by the microbiology laboratory of a single center for four years. The samples of wound, blood, tracheal aspirate, abscess, vagina, cerebrospinal fluid, sputum, and urine culture isolated from 789 patients who were hospitalized in the service, intensive care and outpatient services between 2017-2020 were evaluated retrospectively for Pseudomonas species. Most of culture were urine (42.7%) and sputum cultures (20.4%). Most patients applied to the service were from department of chest diseases (38.6%) or from department of urology (14.3%) or palliative care unit (12.5%). The highest resistances were against cefuroxime, levofloxacin and netilmicin; lowest resistance was against amikacin. The aztreonam, cefepime and gentamicin resistances were significantly reduced by years (P=0.0321, 0.0038 and 0.0004, respectively) while colistin and levofloxacin resistance considerably increased (P<0.0001 and P=0.0407, respectively). Significant decreases were observed in resistance against cefepime, ceftazidime and ciprofloxacin over years (P=0.0321, 0.0038 and 0.0004, respectively). A significant decrease in resistance of strains isolated from urine culture was only observed for cefepime over years (P=0.0003). The resistance of strains isolated from cultures of sputum, urine and respiratory secretions against levofloxacin significantly increased in 2019 while those of wound culture increased in 2020 (P=0.0145). Alterations in the antibiotic resistance profile were detected in patients over years due to frequently varied use of antimicrobials.