Abstract
Ustilagic acid is shown to be relatively inactive against common Gram-positive and Gram-negative pathogenic bacteria and against Mycobacterium tuberculosis. Serum and urine levels in rabbits following oral administration are much lower than the concentration required for in vitro inhibition of most bacteria tested. Human serum depresses the antibacterial effect of ustilagic acid in vitro. The drug had no effect on the course of experimental infection in mice.
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