Abstract
Objective: The objective of this study was to investigate the active compounds derived from Haliclona sp. associated bacteria collected from Untung Jawa Island, Jakarta.Methods: The bacterial isolation, screening of antibacterial activity, purification, and prediction of potential compounds using liquid chromatography– mass spectroscopy/mass spectroscopy (LC–MS/MS) as well as 16S rDNA bacterial characterization were conducted.Results: The potential extract of bacterial strain UJ.17.10-4 showed the highest anti-Gram-positive bacteria. The 16S rDNA gene of this strain had 99% similarity with the actinobacteria Agromyces tropicus. Chemical separation of supernatant extract yielded 13 potent fractions. Identification of antibacterial compounds contained in active fractions using LC-MS/MS were halistanol sulphate C([M+H]+:703), cyclic bis-1,3- dialkylpyridinium([M+H]+: 213.72). In previous research reported that these compounds were isolated from Haliclona sponge and showed anticancer activity.Conclusion: This result supported the ideas that A. tropicus plays an important role in synthesizing, halistanol sulfate C, haliclorensin, and cyclic bis- 1,3-dialkylpyridinium metabolite derived from the host.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Asian Journal of Pharmaceutical and Clinical Research
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
